Well, runners have proven that they can get past monowire fences, cockatrices, ceberus hounds, spirits, elementals, IC, autocannons, and maglocs.
But can they defeat a doorknob connected to 220 volt socket? Or a frozen staircase? Or a living room full of shattered Christmas ornaments. . . Dermal plating doesn't affect the bare soles of your feet, even for trolls. . .